Common Graphics Library (CGL). Volume 1: LEZ user's guide

Users are introduced to and instructed in the use of the Langley Easy (LEZ) routines of the Common Graphics Library (CGL). The LEZ routines form an application independent graphics package which enables the user community to view data quickly and easily, while providing a means of generating scientific charts conforming to the publication and/or viewgraph process. A distinct advantage for using the LEZ routines is that the underlying graphics package may be replaced or modified without requiring the users to change their application programs. The library is written in ANSI FORTRAN 77, and currently uses a CORE-based underlying graphics package, and is therefore machine independent, providing support for centralized and/or distributed computer systems

Raster Metafile and Raster Metafile Translator

The intent is to present an effort undertaken at NASA Langley Research Center to design a generic raster image format and to develop tools for processing images prepared in this format. Both the Raster Metafile (RM) format and the Raster Metafile Translator (RMT) are addressed. This document is intended to serve a varied audience including: users wishing to display and manipulate raster image data, programmers responsible for either interfacing the RM format with other raster formats or for developing new RMT device drivers, and programmers charged with installing the software on a host platform

An Investigation of a 0.05-Scale Model of the XSM-64A Navaho Missile and Booster

An investigation has been conducted in the Langley Unitary Plan wind tunnel to determine the aerodynamic loads and the static longitudinal and lateral stability of a 0.05-scale model of the XSM-64A Navaho missile and booster and its various components. Tests were conducted through a Mach number range of 1.77 to 3.51 with a corresponding Reynolds number range of 2.4 x 10(exp 6) to 2.9 x 10(exp 6). Results are presented for an angle-of-attack range of -8 deg to 4 deg for the missile-booster combination and -10 deg to 10 deg for the missile-alone configuration. Tests for both configurations were conducted through an angle-of-sideslip range of -8 deg to 8 deg. Also presented are some effects on the model characteristics of the deflection of various components including canard, tip aileron, vertical stabilizer, speed brakes, and booster pitch and yaw thrust chambers. The various components on which loads were measured include the wing, tip aileron, rudder, booster, booster separating surface, booster fin, and booster yaw and pitch thrust chambers. These data are presented without analysis

Preliminary Investigation of Rural-Use Aquifers of Boone, Carroll, and Madison Counties, Arkansas

Approximately 500 water wells having driller\u27s lithologic logs were plottedin Boone, Carroll, and Madison Counties, Arkansas. Three aquifers were found to be used by the rural residents and smaller communities. The most shallow of these is the Mississippian Boone-St. Joe aquifer. This aquifer is generally the least productive having a range of .25 to 60 gpm but a median productivity of only 5 gpm. Well depths for the Boone-St. Joe range from 46 to 464 ft. and have a median depth of 225 ft. The Boone-St. Joe aquifer is unconfined to semi-confined and yields sufficient quantities of water only when there is an adequate saturated thickness (generally\u3e100 ft.) and/or a fracture or water-filled cave is intersected. The next aquifer is the first sand below the Chattanooga Shale which can be composed on one to three of the following sandstones: upper Everton, Clifty, and/or Sylamore. The range in yield for this newly designated aquifer is 1 to 70 gpm with a median productivity of 10 gpm. Well depths for the aquifer range from 150 to 824 ft. with a median depth of 460 feet. An isopach map was prepared for this sandstone aquifer zone. There is a rapid thinning trend to the north from 250 ft in central Madison County to 0 ft near the Missouri border. If there is insufficiency or permeability of this aquifer, residents must drill deeper to the Cotter Dolomite. The Cotter-Jefferson City Dolomite is the next aquifer below the Sylamore-Clifty-Everton aquifer. This aquifer zone has a range in yield of 1.5 to 200 gpm and a median yield of 15 gpm. Well depths range from 130 to 1010 ft. with a median depth of 475 feet. A statistical correlation procedure was made among well yield (gpm), photo-lineament proximity, and regolith thickness for all these aquifers in Boone County. The results indicate that more water can be obtained in areas of deep weathering and that deeper weathering is found closer to photo-lineaments. A strong relationship between lineament proximity and yield exists when the aquifers are combined but not for each of the individual aquifers

Weight loss, glycemic control, and cardiovascular disease risk factors in response to differential diet composition in a weight loss program in type 2 diabetes: a randomized controlled trial.

ObjectiveTo test whether a weight loss program promotes greater weight loss, glycemic control, and improved cardiovascular disease risk factors compared with control conditions and whether there is a differential response to higher versus lower carbohydrate intake.Research design and methodsThis randomized controlled trial at two university medical centers enrolled 227 overweight or obese adults with type 2 diabetes and assigned them to parallel in-person diet and exercise counseling, with prepackaged foods in a planned menu during the initial phase, or to usual care (UC; two weight loss counseling sessions and monthly contacts).ResultsRelative weight loss was 7.4% (95% CI 5.7-9.2%), 9.0% (7.1-10.9%), and 2.5% (1.3-3.8%) for the lower fat, lower carbohydrate, and UC groups (P < 0.001 intervention effect). Glycemic control markers and triglyceride levels were lower in the intervention groups compared with UC group at 1 year (fasting glucose 141 [95% CI 133-149] vs. 159 [144-174] mg/dL, P = 0.023; hemoglobin A1c 6.9% [6.6-7.1%] vs. 7.5% [7.1-7.9%] or 52 [49-54] vs. 58 [54-63] mmol/mol, P = 0.001; triglycerides 148 [134-163] vs. 204 [173-234] mg/dL, P < 0.001). The lower versus higher carbohydrate groups maintained lower hemoglobin A1c (6.6% [95% CI 6.3-6.8%] vs. 7.2% [6.8-7.5%] or 49 [45-51] vs. 55 [51-58] mmol/mol) at 1 year (P = 0.008).ConclusionsThe weight loss program resulted in greater weight loss and improved glycemic control in type 2 diabetes

Common Graphics Library (CGL). Volume 2: Low-level user's guide

The intent is to instruct the users of the Low-Level routines of the Common Graphics Library (CGL). The Low-Level routines form an application-independent graphics package enabling the user community to construct and design scientific charts conforming to the publication and/or viewgraph process. The Low-Level routines allow the user to design unique or unusual report-quality charts from a set of graphics utilities. The features of these routines can be used stand-alone or in conjunction with other packages to enhance or augment their capabilities. This library is written in ANSI FORTRAN 77, and currently uses a CORE-based underlying graphics package, and is therefore machine-independent, providing support for centralized and/or distributed computer systems

Leu8 and Pro8 oxytocin agonism differs across human, macaque, and marmoset vasopressin 1a receptors

Oxytocin (OXT) is an important neuromodulator of social behaviors via activation of both oxytocin receptors (OXTR) and vasopressin (AVP) 1a receptors (AVPR1a). Marmosets are neotropical primates with a modified OXT ligand (Pro8-OXT), and this ligand shows significant coevolution with traits including social monogamy and litter size. Pro8-OXT produces more potent and efficacious responses at primate OXTR and stronger behavioral effects than the consensus mammalian OXT ligand (Leu8-OXT). Here, we tested whether OXT/AVP ligands show differential levels of crosstalk at primate AVPR1a. We measured binding affinities and Ca2+ signaling responses of AVP, Pro8-OXT and Leu8-OXT at human, macaque, and marmoset AVPR1a. We found that AVP binds with higher affinity than OXT across AVPR1a, and marmoset AVPR1a show a 10-fold lower OXT binding affinity compared to human and macaque AVPR1a. Both Leu8-OXT and Pro8-OXT produce a less efficacious response than AVP at human AVPR1a and higher efficacious response than AVP at marmoset AVPR1a. These data suggest that OXT might partially antagonize endogenous human AVPR1a signaling and enhance marmoset AVPR1a signaling. These findings aid in further understanding inconsistencies observed following systemic intranasal administration of OXT and provide important insights into taxon-specific differences in nonapeptide ligand/receptor coevolution and behavior

Bulletin No. 23: Plants and Animals of the Estuary

Descriptions and illustrations of over 70 estuarine species

Graphics mini manual

The computer graphics capabilities available at the Center are introduced and their use is explained. More specifically, the manual identifies and describes the various graphics software and hardware components, details the interfaces between these components, and provides information concerning the use of these components at LaRC

An assessment of the screening method to evaluate vaccine effectiveness: the case of 7-valent pneumococcal conjugate vaccine in the United States.

The screening method, which employs readily available data, is an inexpensive and quick means of estimating vaccine effectiveness (VE). We compared estimates of effectiveness of heptavalent pneumococcal conjugate vaccine (PCV7) against invasive pneumococcal disease (IPD) using the screening and case-control methods. Cases were children aged 19-35 months with pneumococcus isolated from normally sterile sites residing in Active Bacterial Core surveillance areas in the United States. Case-control VE was estimated for 2001-2004 by comparing the odds of vaccination among cases and community controls. Screening-method VE for 2001-2009 was estimated by comparing the proportion of cases vaccinated to National Immunization Survey-derived coverage among the general population. To evaluate the plausibility of screening-method VE findings, we estimated attack rates among vaccinated and unvaccinated persons. We identified 1,154 children with IPD. Annual population PCV7 coverage with ≥1 dose increased from 38% to 97%. Case-control VE for ≥1 dose was estimated as 75% against all-serotype IPD (annual range: 35-83%) and 91% for PCV7-type IPD (annual range: 65-100%). By the screening method, the overall VE was 86% for ≥1 dose (annual range: -240-70%) against all-serotype IPD and 94% (annual range: 62-97%) against PCV7-type IPD. As cases of PCV7-type IPD declined during 2001-2005, estimated attack rates for all-serotype IPD among vaccinated and unvaccinated individuals became less consistent than what would be expected with the estimated effectiveness of PCV7. The screening method yields estimates of VE that are highly dependent on the time period during which it is used and the choice of outcome. The method should be used cautiously to evaluate VE of PCVs